具核梭杆菌代养、敲除与突变体文库

具核梭杆菌（Fusobacterium nucleatum）是一种革兰氏阴性专性厌氧无芽孢杆菌，是人类口腔常驻菌群，与牙周炎、炎症性肠病、结直肠癌等疾病密切相关，其致炎、促癌机制是当前研究热点。

服务内容

  • 各类组织中具核梭杆菌分离培养
  • 具核梭杆菌代养服务
  • 具核梭杆菌敲除株构建
  • 具核梭杆菌转座子突变体文库构建

现货菌株：具核梭杆菌 ATCC 25586

参考文献

  • Umana A, Nguyen T T D, Sanders B E, et al. DNA methyltransferase enhanced Fusobacterium nucleatum genetics[J]. bioRxiv, 2022: 2022.07.20.500824.
  • Casasanta M A, Yoo C C, Udayasuryan B, et al. Fusobacterium nucleatum host-cell binding and invasion induces IL-8 and CXCL1 secretion that drives colorectal cancer cell migration[J]. Science Signaling, 2020, 13(641): eaba9157.
  • Wu C, Chen Y W, Scheible M, et al. Genetic and molecular determinants of polymicrobial interactions in Fusobacterium nucleatum[J]. Proceedings of the National Academy of Sciences, 2021, 118(23): e2006482118.
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